Differential Induction of Apoptosis by Apple Procyanidins in TRAIL-Sensitive Human Colon Tumor Cells and Derived TRAIL-Resistant Metastatic Cells
نویسندگان
چکیده
INSERM U682, Laboratory of Nutritional Cancer Prevention, Strasbourg, France [M.-E. Maldonado-Celis, S. Bousserouel, F. Gossé, F. Raul]; University of Strasbourg, Faculty of Medicine, Strasbourg, France [M.-E. Maldonado-Celis, S. Bousserouel, F. Gossé, F. Raul]; Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD), Strasbourg, France [M.-E. Maldonado-Celis, S. Bousserouel, F. Gossé, F. Raul]; Escuela de Nutrición y Dietética, Universidad de Antioquia, Medellín, Colombia [M.-E. Maldonado-Celis]; CNRS UMR7081, University of Strasbourg, Faculty of Pharmacy, Illkirch, France [C. Minker, A. Lobstein]
منابع مشابه
Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells.
INTRODUCTION The nuclear factor-kappaB (NF-NF-κ) has been shown to upregulate pro-apoptotic mediators such as TRAIL-DR4/-DR5 receptors and the p53 transcription factor depending on the type of stimulus and the cell type involved. Previously, apple procyanidins (Pcy) have been shown to upregulate the expression of TRAIL-DR4/-DR5 and thereby overcoming the resistance of human colon cancer-derived...
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SCOPE The aim of this work is to identify which proapoptotic pathway is induced in human colon cancer cell lines, in contact with proanthocyanidins extracted from various berries. METHODS AND RESULTS Proanthocyanidins (Pcys) extracted from 11 berry species are monitored for proapoptotic activities on two related human colon cancer cell lines: SW480-TRAIL-sensitive and SW620-TRAIL-resistant. A...
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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in MIT6 cells derived from primary oral squamous cell carcinoma (OSCC), whereas it does not induce apoptosis in MIL6 cells derived from metastases. The present studies were performed to examine whether activation of c-Jun NH2-terminal kinase (JNK) is implicated in the differential sensitivity to TRAIL-induce...
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